Bob Bickler is a Technical Specialist with 38 years of chromatography experience and writes for The Flash Purification Blog.
Recently, Mr. Bickler wrote a post that outlines something we've been telling people for years:
Here's an excerpt:
I know your time is valuable but investing 10 minutes of it running TLC prior to your flash purification will give you much better separations, increased fraction purity, and reduce the amount of wasted solvent. You really have nothing to lose and everything to gain.
In addition to Flash Chromatography, we believe the same principle applies to HPLC and other separation methods.